Endocrine Abstracts

Wistar rats (male) were divided into three groups – group A (GA) served as control, group B (GB) were daily administered orally chlorpyrifos at a dose of 5 mg/kg b wt. and animals in group C (GC) received daily an oral administration of chlorpyrifos at a dose of 10 mg/kg b wt. Rats were sacrificed on 1st, 2nd, 4th, 6th, and 8th week after initiation of the experiment. Changes in serum electrolytes (calcium, phosphate and magnesium) and endocrine glands (calcitonin cells a...

Introduction: Fetal goiter is a rare condition. The incidence of goitrous hypothyroidism is 1/30 000–50 000 live births. We describe a case of antenatal fetal goiter that vanished upon delivery and was not detected in the newborn. The case report is followed by a discussion wherein we review the literature on thyroid problems in pregnancy and management of fetal goiter.Case report: A 27-year-old known hypothyroid woman with bichorial biamniotic preg...

Studies show conflicting results regarding possible excess risk of atypical fractures associated with bisphosphonate (BSP) use. Since BSP reduces bone remodeling, they freeze the skeleton allowing accumulation of microcracks over time leading to atypical fractures. We present two cases of atypical fracture and discuss on monitoring therapy and drug holiday in chronic BSP users.Methods: Over the period of last 8 months we diagnosed two cases of alendronat...

Introduction: Primary Hypoparathyroidism presents most commonly in childhood to early adolescence. Disease may be familial or sporadic.Most commonly hypoparathyroidism is secondary to neck operations especially Thyroid surgeries. Primary can be congenital eg- Digeorge syndrome or inherited by AD, AR or X linked mediated.We report 2 cases of late onset seizure due to Digeorge syndrome and Autosomal Dominant Hypoparathyroidism in a elderly lady.Case Report...

Background: Growing evidence suggests that hypothalamic lipid sensing plays a key role in controlling food intake, fat deposition and energy balance and that its dysregulation could lead to obesity and type 2 diabetes (T2D). Recent investigations reported that sphingosine-1-phosphate (S1P) is involved in the hypothalamic control of energy homeostasis. Intra-cerebroventricular administration of S1P decreased food intake and increased energy expenditure in rodents.<p class="...

Background: There is no effective medical treatment available for non-functioning pituitary neuroendocrine tumours (NF-PitNETs). Recurrence (7-12%) or incomplete resection (30-45%) is a common feature. Thus, finding novel medical therapies to help the management of these tumours would be of great value. By using high-throughput mass spectrometry combined with functional characterisation, we explored novel therapeutic targets for NF-PitNETs.<p class="abstex...